objective To Explore Clinical effects of the ful laparoscopic splenectomy and pericardial devascularization(LSPD) with Standardized nurse cooperation for portal hypertension. Methods: Retrospective analysis ofclinical databetweenJanuary 20102013February20 cases of laparoscopic splenectomy pericardial Devascularization, analyze blood loss, operative time and postoperative complication rate. Results: With Standardized nurse cooperation, 20 cases were completed in ful endoscopic, surgical time 180~ 430min, average (265 ± 42) min. Intraoperative blood loss 150 ~ 1050 ml, average (450 ± 240) m1. 3 cases of postoperative pleural effusion, l case of portal vein thrombosis ; 2 cases of low - moderate fever , no intraoperative and perioperative mortality. Postoperative hospital stay was 8 ~ 14d, the average (8.5 ±4.0) d. Conclusions: The LSPD is a safe, minimal y invasive surgical approach for portal hypertension, with standardized nurse cooperation can improve surgical efficiency and shorten the operation time.