In order to explore the effect of early rehabilitation nursing on patients with spinal cord injury. Methods: a comprehensive system of early rehabilitation nursing intervention on patients in 2011 July -2013 year in February to our hospital 19 patients with spinal cord injury, time observation, was performed on al patients with Barthel index and FIM evaluation before admission, after 4-5 months of rehabilitation nursing intervention, re assessment of Barthel index and FIM score. Conclusion: early in patients with spinal cord injury rehabilitation nursing intervention, can significantly improve the self-care ability of patients, improve the quality of life.