Objective To study the curative effect of Vitapex paste without sinus periapical periodontitis of intracanal medicament on chronic. Methods of chronic non sinus periapical patients, formocresol root traditional dressing for a week, but the pain is stil not lost teeth 70, grouped according to the visiting time randomly, the first group of 35 teeth with Vitapex paste; second groups of 35 teeth camphor phenol and ornidazole with powder and into a thin paste; respectively with absorbent paper points with the above two drugs to seal root canal drug a week, scheduled to visit. If the patient, not satisfied with the results, percussion pain is stil not disappeared, respectively according to the above two kinds of methods to seal a week, or one more week. Results X2 analysis showed that there was significant difference, effect of two kinds of drugs, Vitapex paste group was significantly better than that of camphor phenol with Ornidazole combined group, but between the two groups in the number of seal medicine began to bear fruit is not obtained statistical y significant results. Conclusions X2 test statistical analysis showed that, the curative effect of Vitapex paste on refractory periapical disease significantly.