Objective: To observe the clinical effect of high dose methylprednisolone in the treatment of acute myelitis, method: 60 cases of patients with acute myelitis were randomly divided into observation group and control group with 30 cases in each group, methylprednisolone impact treatment observation group were given methylprednisolone, control group were given dexamethasone treatment, curative effect.Results: in the observation group were markedly effective rate was 86.6%, significantly better than the control group 40% (P<0.05);observation group patients and improve the time, in muscle urinary recovery time and ambulation etc. was shorter than that of the control group were (P < 0.05). Conclusion: the application of methylprednisolone in treatment of acute myelitis, safe and effective, and worthy of further promotion.