Objective: To study the clinical effect and nursing intervention ofendoscopic treatment of gastrointestinal polyps. Methods: in the implementation of the hospital received endoscopic gastrointestinal polyps treated with endoscopic patients randomly selected 200 cases analysis. Which is divided into the control group and experimental group, to the control group,nursing intervention for the experimental group adopted conventional, nursingprofessional,compared two groups of patients with operation treatment time and patient satisfaction. Results:two patients were successful operation, nocomplications, while at the same time and satisfaction of operation treatment of the experimental group were significantly (P < 0.05), clinical comparability.Conclusion: for gastrointestinal polyp patients undergoing endoscopic treatment, nursing intervention professional at the same time, can reduce thepatient's psychological anxiety, improve the treatment effect, improve patientsatisfaction.