Objective: Analysis on factors cause hypoglycemia coma caused by alcohol poisoning and first aid care methods, to summarize the clinical experience, provide a theoretical basis for the future work of emergency rescue hypoglycemia. Method:Ethanol induced hypoglycemic coma patients as the research object, on its with the emergency nursing. Result:The hypoglycemia coma patients first aid ethanol poisoning is to find out the cause of hypoglycemia, and adopt proper nursing intervention on patients, can significantly improve the treatment effect, reduce the recurrence rate.