联合检测抗CCP抗体与RF对类风湿关节炎诊断的临床意义
To evaluate the clinical diagnosic value of anti-cyclic citrul inated peptide(anti-CCP) antibody and rheumatoid factor(RF) in patients with rheumatoid arthritis(RA)
赵海燕1
作者信息
- 1. 辽宁省大连市旅顺口区人民医院检验科 116041
- 折叠
摘要
目的：探讨联合检测抗环瓜氨酸肽抗体（抗CCP抗体）及类风湿因子（RF）对类风湿性关节炎（RA）的临床诊断价值。方法：分别检测130例RA患者，98例非RA的风湿病患者及40例正常人血清的抗CCP抗体和RF。结果：抗CCP抗体和RF联合检测的特异性，阳性预测值，阳性似然比，阴性似然比与任何单一项检测比较均有显著差异（P<0.05）。结论：联合检测抗CCP抗体和RF可明显提高类风湿性关节炎的诊断率。
Abstract
Objective: To evaluate the clinical diagnosic value of anti-cyclic citrul inated peptide(anti-CCP) antibody and rheumatoid factor(RF) in patients with rheumatoid arthritis(RA). Methods: Anti-CCP antibody was defected by quantitative ELISA and rheumatoid factor by BNP nephelometer in 130 cases of RA, 98 cases of non-RA rheumatic diseases and 40 cases of healthy individuals. Results: The diagnosis specificity, positive predictive value, positive/negative likelihood ratios of combinate determination of anti-CCP antibody and RF were significantly higher than either one. Conclusion: The measurements of anti-CCP antibody and rheumatoid factor wil remarkably improve the accuracy of diagnosis of RA.
关键词
抗CCP抗体/类风湿因子/类风湿性关节炎Key words
Anti-cyclic citrul inated peptide antibody/Rheumatoid factor/Rheumatoid arthritis引用本文复制引用
出版年
2014
NETL
NSTL
万方数据