[Objective] Estrogen in postmenopausal women with coronary heart disease incidence effects. [Methods] Analysis menopausal women estrogen levels decline, the female estrogen regulation of lipid metabolism and cardiovascular system decreases, slowing blood flow, coronary arterial stenosis lipid deposition. Leading to myocardial ischemia and other organ diseases.[Conclusion]Postmenopausal women given estrogen replacement therapy can prevent the occurrence of coronary heart disease in postmenopausal women.