Objective: To explore the diagnosis and treatment of primary brain stem injury.Method:Retrospective analysis of the clinical data of 56 patients with primary brain stem injury. Results: In 56 patients after treatment, the good recovery in 13 cases (23.2%), moderate disability in 15 cases (26.8%), severe disability in 9 cases (16.1%), 19 cases of death (33.9%).Observation:Adopt comprehensive treatment can improve the prognosis, improve the therapeutic effect, reduce mortality and disability, rate of primary brain stem injury.