Objective: To investigate the therapeutic effect of vertebroplasty and clinical manifestations of spinal osteoporotic fractures. Methods: osteoporotic vertebral fractures 46 patients, grouped by bal ot, the control group of 23 patients in the experimental group 23 cases. Control group using traditional drug treatment. The experimental group vertebroplasty treatment, patients were observed and recorded after treatment VAS score. Results: The VAS scores are general y lower than in the control group VAS score. Conclusion: vertebroplasty treatment of osteoporotic spinal fractures clinical effect is obvious. Instead of the traditional drug treatment and to promote the use of clinical recommendations.