Mutagenicity test of magnetic composites material for interface fixation
Objective To evaluate the bio-compatibility and safety of the magnetic composite(Nano-HA/PLLA/Fe2O3) from the aspects of inherited toxicology of it for the clinical use of interface fixation.Methods Produce Nano-HA/PLLA/Fe2O3 magnetic composites material and it’s diffusion and test the diffusion through Ames test.The observation markers of the test are the mutagenes rates of murine typhoid salmonel a (MR). Results The mutagenesis rates of murine typhoid saline monel a in the experimental groups of al dosage levers are less than 2. Conclusion The magnetic composites material wil not cause the increase of the back mutation in murine typhoid salmonel a which show that this artificial bone wil not cause gene mutation.
hydroxyapatitenanometerinterface fixationmutagenicity test
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