目的：探讨子宫螺旋动脉血流参数联合血清孕酮、β-H C G检测预测早期先兆流产的临床研究价值。方法：选取我院2011年至2013年就诊的具有先兆流产临床症状的120例患者，根据临床症状及妊娠结局分为先兆流产组93例，停经时间5～8周；难免流产组27例，停经时间6～8周。另选取120例正常妊娠妇女做对照组，停经时间5～8周，分别比较三组患者子宫螺旋动脉血流参数、血清孕酮、β-HCG及联合检测结果。结果：先兆流产组子宫螺旋动脉RI、PI值较对照组升高，差异明显，具有统计学意义（P＜0.05）；难免流产组较先兆流产组R I值更高，差异明显，具有统计学意义（P＜0.05）。正常组及先兆流产组血清孕酮、β-HCG值均显著高于难免流产组（P＜0.05），具有统计学意义；子宫螺旋动脉RI联合孕酮、β-HCG检测特异性及准确性较其他单独检测指标升高，差异明显，具有统计学意义（P＜0.05）。结论：联合子宫螺旋动脉血流参数、血清孕酮及β-H C G检测可提高早期先兆流产的检出率，且能在一定程度上反映先兆流产预后，为临床提早展开治疗提供有力依据，值得临床推广。
Clinical Research of Combining Uterine Spiral Artery Blood Flow Parameters,Serum Progesterone and β-HCG Test in Prediction Outcome of Early Threatened Abortion
objective: To investigate the clinical value of uterine spiral artery blood flow parameters,serum progesterone and β-HCG Test in prediction outcome of early threatened abortion. Methods: 120 cases of threatened abortion patients were selected in our hospital from 2011 to 2013,among whom 93 cases of threatened abortion were divided into the first group with a 5 ~ 8 weeks of menopause , according to the clinical symptoms and pregnancy outcome; 27 cases of Inevitable abortion into the second group with a 6 ~ 8 weeks menopause. Another 120 cases of normal pregnant women(the third group) with a 5 ~ 8 weeks of menopause were also selected to compare the results of examing alone with the results of joint detection .Results: The uterine spiral artery RI, PI of the first group are comparatively higher than the other groups with statistical significance (P < 0.05);The uterine spiral artery RI of the second group is even higher than the first group ,which is obviously different with statistical significance (P < 0.05); The serum progesterone and β-HCG of the first and the third group were obviously higher than that of second group with statistical significance (P < 0.05);the above results show that the specificity and accuracy of combining uterine spiral artery blood flow parameters,serum progesterone and β-HCG test are much higher than other measurements alone, which is obviously different with statistical significance (P < 0.05). Conclusion: combining uterine spiral artery blood flow parameters,serum progesterone and β-HCG test can improve the detection rate of early threatened abortion, and to a certain extent, it can reflect the prognosis of threatened abortion, thus providing powerful basis for early clinical treatment, which is worth clinical promotion.
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