Objective: To investigate the effective evaluation of operations in treating OSAHS and change of serum EPO levels. Methods:115 patients with OSAHS were treated through UPPP. EPO levels were col ected. Results: 89 patients were improved (77.4%) ; 26 patients were invalid(22.6%).EPO were significant than postoperative patients and normal adults(P<0.05). Conclusion: The UPPP was efficacious in treatment of OSAHS.The levels of EPO and thrombo-disease were decreased through efficacious treatment.