Objective: To observe the sedative effect of dexmedetomidine in aged patients with combined spinal epidural anesthesia (CSEA). Methods:120 patients, ASA Ⅱo r ASAⅢ, scheduled for with CSEA, were equal y randomized into five groups: control group (group A), propofol group (group B) and dexmedetomidine group (C1, C2, C3 groups), and MAP, HR, RR, SpO2 and Ramsay score were recorded before anesthesia, after CSEA, and 5, 15, 30 and 60 min after sedative administration, Al patients were fol owed up 24 h postoperatively to observe the amnestic effect during operation. Results: Ramsay scores were higher in C1, C2, C3, B groups at T3-T6 than at T1 (P<0.05) . Ramsay scores were higher in C2,C3, B groups than A group at T4-T6 (P<0.05) . HR decreased in C3 group than other grous at T4-T6 ( P<0.05) . MAP decreased in B group than other groups at T5 and T6 (P<0.05). Amnestic effects in dexmedetomidine groups were higher comparing to A group (P<0.05), while had no difference comparing to B group. Conclusion: Dexmedetomidine 0.5μg/kg fol owed by 0.2-0.5μg?kg-1?h-1intravenous infusion caused effective sedation and amnestic effect during operation for aged patients with CSEA with no respiratory depression and cycle inhibition.
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