盐酸戊乙奎醚对体外循环患者IL-6和IL-10的影响
Effects of penehyclidine hydrochloride on IL-6 and IL-10 induced by cardiopulmonary bypass
胡彦艳 1黄爱兰 1卢小玲 1叶凤青 1朱蔚琳 1万福红 1黄中华1
作者信息
- 1. 广西壮族自治区人民医院麻醉科 广西南宁 530021
- 折叠
摘要
目的：探讨盐酸戊乙奎醚对体外循环（CPB）后IL-6和IL-10的影响。方法：选择ASAⅡ～Ⅲ级择期CPB下行心脏瓣膜置换手术患者40例，随机分为两组（n＝20）：盐酸戊乙奎醚（P）组和对照(C)组。分别在麻醉诱导后CPB前5min，P组静注PHC 0.1mg/kg，C组静注等量生理盐水。两组分别于麻醉前（T0）、主动脉阻断5 min（T1）、CPB结束(T2)、术后48h（T3）和术后1W（T4）抽血ELISA法测定IL-6和IL-10的浓度。结果：与T0比较，两组在T1～T4两指标均升高；与C组比较，P组的IL-6在T1～T3时下降、IL-10在T1～T4升高（P＜0.05）。结论：盐酸戊乙奎醚可减轻CPB后的炎性反应，增强抗炎作用。
Abstract
Objective To investigate the effects of penehyclidine hydrochloride on IL-6 and IL-10 induced by cardiopulmonary bypass (CPB) .Methods Forty patients undergoing valve replacement with CPB were randomly divided into two groups(n=20): group PHC and group C. Pnehyclidine hydrochloride 0.1mg/kg was injected intravenously before 5min CPB.Blood samples were colected for IL-6 and IL-10 before CPB (T0),after 5min aorta block(T1),CPB cease(T2)and 48h (T3)and 1w(T4) after the operation .Results The levels of IL-6 was significantly lower and IL-10 was significantly higher in group P at T1~T3 than those in group C(P<0.05). Conclusion Penehyclidine hydrochloride could inhibit inflammatory response induced by cardiopulmonary bypass and may be helpful in preventing the systemic inflammatory response .
关键词
盐酸戊乙奎醚/体外循环/炎性反应/白介素Key words
penehyclidine hydrochloride/cardiopulmonary bypass/inflammatory response/Interieuki引用本文复制引用
出版年
2014
NETL
NSTL
万方数据