objective to comprehensive care model was applied to patients with atypical pain in patients with acute myocardial infarction disease during the implementation of nursing clinical effect were studied. Methods wil our hospital 80 cases of patients with atypical pain in patients with acute myocardial infarction disease were randomly divided into control group and observation group, on average, 40 cases in each group. The conventional myocardial infarction care model to control patients during during the implementation of nursing; Using comprehensive nursing care model to implement nursing observation group of patients during treatment. Results myocardial infarction patient treatment effect of observation group was obviously better than the control group; Myocardial infarction, nursing service satisfaction is significantly higher than control group; A total of hospitalized time significantly shorter than the control group. Conclusion comprehensive nursing mode of patients with atypical pain in patients with acute myocardial infarction disease during the implementation of nursing clinical effect is very obvious.