objective: to study the analysis of intravenous thrombolysis in acute myocardial infarction and coronary artery intervention treatment of comparative. Methods: select 78 cases from our hospital patients with acute myocardial infarction (mi) is studied, and according to the treatment wil be divided into the treatment group (treated with coronary artery intervention treatment method) and the control group (treatment, intravenous thrombolysis treatment), each for 39 cases, compared two groups of patients with infarction related blood vessels, the condition of heart function, mortality rate and length of hospital stay. Results: compared with two groups of patients after infarction related blood vessels, the condition of heart function, mortality rate and length of hospital stay, the obvious difference, P < 0.05. Conclusion: coronary artery interventional therapy in the treatment of acute myocardial infarction disease clinical effect significantly, it can effectively increase the infarction related blood vessels, improving the rate of patients with cardiac function, reduce mortality and shorten their hospital stay.