objective: to study the clinical effect of laparoscopic treatment of acute gal stone disease. Methods: our hospital in recent years were treated with laparoscopic and open surgical treatment of acute gal stone disease patients as observation group (40 cases) and the reference group (40 cases), on two groups of patients with intraoperative blood loss, operative time, postoperative drainage time and the average hospitalization time observation analysis, statistics of two groups of patients with postoperative complications. Results: to observe the operation time is longer than the reference group, but is no statistical significance (P > 0.05); Observe the operative time, postoperative drainage time and the average length of hospital stay were significantly shorter than the reference group (P < 0.05); To observe the postoperative complication rate is lower than the reference group (P < 0.05). Conclusion: laparoscopic treatment in patients with acute gal stone disease less intraoperative blood loss, less postoperative complications, promote patients recover.