Clinical observation on the effect of neoadjuvant intraarterial chemotherapy in the treatment of advanced gastric cancer with oxaliplatin
Objective To study of neoadjuvant chemotherapy for advanced gastric cancer postoperative pathological changes and clinical effect. Methods: 50 cases of advanced gastric cancer were randomly divided into two groups, the study group of 25 cases of arterial infusion chemotherapy with oxaliplatin; the control group of 25 cases of systemic venous chemotherapy. The former uses Seldinger technology, according to lesion location selectivearterial corresponding, oxaliplatin 85mg/m2 chemotherapy regimen tegafur, doxorubicin, 1000mg/m2 25mg/ m2. The two cycle 7-10 days after operation treatment; the latter 25 patients selected 85mg/m2 D1 oxaliplatin, calcium folinate 200 mg/m2 D1-2, fluorouracil 400 mg/m2ivd1-2, 600 mg/m2 CIVd1-2 fluorouracil. The two cycle of chemotherapy treatment 10-14 days after operation, the postoperative gastric cancer specimens for examination and surgery pathology after 2 year survival rate. Results: the two groups of postoperative pathology change and total effective rate were 55.6%, 36.52%. A significant difference between two groups (P < 0.05). The 2 year survival rates were 70% and 54.2%, a significant difference between two groups (P < 0.05). Conclusion: neoadjuvant preoperative interventional chemotherapy containing oxaliplatin is a safe, effective, feasible treatment method for advanced gastric cancer, complications less than systemic chemotherapy, the operation resection rate and survival rate increased, to study the large sample.
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