objective to study the analysis of cardiovascular internal medicine clinical therapeutic effect in patients with acute angina pectoris. Methods select our hospital in January 2012 - December 2013 86 cases of acute cardiovascular internal medicine angina patients as the research object, the random is divided into two groups, control group, 40 patients were given conventional treatment, 46 patients in the conventional treatment group on the basis of giving clopidogrel treatment, two groups of clinical curative effect observation. Results clinical observation group the total effective rate was 93.5%, significantly higher than that of control group 72.5%, statistical y significant difference (p < 0.05); Group of blood pressure and cholesterol level was observed after treatment significantly better than control group, the difference is statistical y significant (p < 0.05). Conclusion to adopt reasonable and effective treatment, and the basis of the corresponding drug treatment can significantly improve the clinical curative effect, improve the quality of survival, is worth popularizing application.