Objective:To evaluate the efficacy and asfety of venlafaxine in the treatment of depression.Methods:76 depression patients were randomly assigned to venlafaxine group(n=38)and amitriptyline group (n=38)for 6weeks.Clinical efficacies were assessed with Hamilton Depression Rating Scale(HAMD)and adverse effects with the Treatment Emergent Symptoms Scale(TESS)before teratment and at the ends of the 1st,2nd,4th and 6th week treatment.Results:Excellece and effectiveness rates were respectively 73.7%and 89.5% in the research group and 68.4%and 86.8% in the control group.Since the end of the 1st week,The HAMD scores of both groups lowered very significantly compared with pretreatment (both P<0.01) and did continiously fol owing time of therapy lasting;;at the ends of both groups lowered very significantly compared with pretreatment (both P<0.01)and did continiously fol owing time of therapy lasting;at the ends of the 2nd and 4th week,those did more significantly in the research than in the control group(P<0.05).Their extents were mild and could relieve and disappear after symptomatic treatment.Conclusion:Venlafaxine has equivalent efficacy to amitriptyline,higher safety and better compliance,and takes fefects faster in the treament of depression.
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