Objective: To study the imaging method of diagnosis and differential diagnosis in detecting tuberculoma . Methods: Imageology approach was applied to diagnose 80 cases of tuberculosis lesions combined the form of spherical focus. Results: The results showed that 55 cases had get tuberculoma, and the other 25 cases had developed lung cancer. Conclusion:The morphologic characteristics,calcification feature and surrounding imaging display are main points in tuberculoma. diagnosing.