Objective: To study the differences between patients with depression and anxiety neurosis patients test results of MMPI. Methods: 54 patients with depressive disorder were divided into depression group, 48 patients with anxiety neurosis patients were divided into anxiety group, and then selected 48 normal persons as control group, three groups of samples for personality test using MMPI, and compared the test results. Results: in the control group and the anxiety group were Pd, Hs, D, Pa, Pt, Hy scores were significantly different among different P < 0.05, and depressive patients were Pa, Pt, Pd, Hy, Sc, Ma, Hs, D, Si scores were significantly different among different P < 0.05. Conclusion: there was significant difference between MMPI test results of patients with depression and anxiety neurosis patients and ordinary people, at the same time, the test results of two patients with MMPI disease are part of the same. In the treatment of two patients, to take appropriate treatment measures according to the measured MMPI data.