objective to mifepristone compatibility in accordance with the sand acridine for nul iparous the efficacy and safety of middle gestation induced labor. Methods choose 16 ~ 24 weeks gestation voluntary requirements certificate, 200 cases of termination of pregnancy and no taboos. Randomly divided into two groups, group A group of100 cases for observation, 150 mg three times oral mifepristone, A second time after taking the medicine according to the sand acridine 100 mg of amniotic cavity injection induced labor, group B as control group of100 cases, pure line amniotic cavity injection acridine 100 mg induced labor in accordance with the sand. Observe the change of the two groups of cervical, contractions start time, the total labor time, soft birth canal injury, placental membranes residue, postpartum hemorrhage, the success rate of induced labor. Conclusion mifepristone compatibility in accordance with the sand acridine for nul iparous mid-term gestation induced labor can speed up the progress in labor, reduce the complications.