目的：探讨血液透析早期干预钙磷代谢对肾性骨病患者的影响。方法：选取来我院行血液透析治疗的肾脏疾病患者96例，按照知情同意原则随机分为两组，观察组和对照组各48例患者。观察组患者给予血液透析早期干预，患者治疗目标为血钙、血磷和PTH维持在临床实践指南推荐目标范围内，在饮食控制方面应用碳酸钙降磷、骨化三醇控制PTH方式进行干预。对照组患者不进行以上相关干预，仅给予常规的血液透析护理和相关饮食指导。结果：观察组患者临床研究后血钙、血磷和P T H的平均值与临床研究前相比没有显著变化（P>0.05）；对照组患者临床研究后血钙、血磷没有显著变化，但其P T H的平均值与临床研究前相比有显著升高（P<0.05）。结论：血液透析早期干预钙磷代谢，能够延缓钙磷沉积，控制甲状旁腺激素升高，对于缓减患者痛苦，改善患者生存质量具有重要意义。
Objective: To investigate the impact of early intervention hemodialysis on calcium and phosphorus metabolism in patients with renal osteodystrophy. Methods: 96 patients with kidney disease to our hospital hemodialysis treatment, according to the principle of informed consent were randomly divided into two groups, the observation group and control group of 48 patients. The patients given early intervention in hemodialysis patients with treatment goals as calcium, phosphorus and PTH maintained within the target range of clinical practice guidelines recommend the application of calcium carbonate in terms of reduced phosphorus diet, calcitriol control PTH way to intervene. More than the control group of patients without relevant interventions, given only conventional hemodialysis care and related dietary guidance. Results: No clinical studies of patients in the observation group after pre-clinical studies and the mean serum calcium, phosphorus and PTH compared to the significant changes (P> 0.05); calcium, phosphorus and no significant change in the control group of patients in clinical studies, but its compared to the average of the pre-clinical studies of PTH were significantly increased (P <0.05). Conclusion: Early dialysis blood calcium and phosphorus metabolism intervention can delay the deposition of calcium and phosphorus, parathyroid hormone increased control for mitigating the suffering of patients, improve the quality of life of patients is important.
hemodialysisearly interventioncalcium and phosphorus metabolismrenal osteodystrophy
NETL
NSTL
万方数据
