Purpose:To figure out the best way of dissolving the crystal ization of mannitol.Methods:From Jan to Dec in 2013,728 bottles of 20% crystal ization of mannitol injection were randomly divided into two groups.Boiling method was used to dissolve the 362 bottles of 20% crystal ization of mannitol injection in the control group;while the electric heater method was used in the experimental group.The label damage, shedding, bottle rupture of the mannitol injection by two methods of dissolving the crystal ization were observed;the dissolving temperature was 36.4±2.98℃ with no re-crystal ization after placement.While in the control group,8 bottles were broken;169 labels were shedded,103 labels were damaged.The temperature was high at 97.25±2.60℃ after dissolving and 282 bottles were re-crystal ized after placement. There was statistical y significant difference (P<0.01) between the two groups. Conclusion:electric heater method was better than boiling method in dissolving and saving the crystal ization of mannitol.
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