Effects of dexmedetomidine premedication on the circulation in patient with hypertension during anesthetic induction and tracheal intubation
Objective: To investigate the effects of demedetomidine premedication on the circulation in patients with hypertension during anesthetic induction and tracheal intubation. Methods: Forty patients with hypertension scheduled for spinal surgery were enrol ed in this study. Patients were randomized into two group (n=20 each):group C=control; group D=dexmedetomidine. Dexmedetomidine (0.5ug/kg) were administered to patients in group D by a infusion pump 10min prior to anesthetic induction. While patients in group C received the same volume normal saline. The infusion lasted 10 min. BP( Blood pressure)HR(heart rate)were respectively recorded at the fol owing time points, before infusion of dexmedetomidine (T0), immediately before tracheal intubation(Tl),1, 3, 5 min after tracheal intubation(T2-5).Results: Compared with T0,In group N,BP were significantly decreased at T1 then increased at T3 and T4(P<0.05) .These variables had no significant change in group D. Statistical y significant differences were found between the two groups(P<0.05).The level of HR was significantly lower at Tl-5 than that at T0 in group D, Statistical y significant differences were found between the two groups(P<0.05). Conclusion: Dexmedetomidine premedication can safely and effectively al eviate the cardiovascular response and keep the stability of circulation in patients with hypertension during anesthetic induction and tracheal intubation.
NETL
NSTL
万方数据
