Objective: To evaluate the low birth weight neonates and normal birth weight newborns ,compared whether the nerve behavior ability (NBNA) is affected . Methods:the 65 cases of low birth weight (BW < 2500g) newborns do NBNA test after they were birth respectively 3-4 days and 25-28 days , and compared with 78 cases of normal birth weight infants .Results: To measure the NBNA after 3-4 days and 25-28 days they were born,al NBNA measurements of the low birth weight infants were significant difference compared with the control group(al P <0.001),the comparison of the NBNA scores and total score is significant difference between the low birth weight infants after they were born 3-4 days and 25-28 days(al P <0.001); conclusion: The NBNA value of low birth weight infants is lower than normal birth weight infants; with neonatal growth and development, the NBNA value wil continue to improve.