Purpose: To evaluate the clinical diagnostic value with low dose multi-detector CT (MDCT) in preterm infants with bronchopulmonary dysplasia (BPD). Methods: 22 preterm infants clinical y diagnosed with BPD underwent low dose MDCT scanning and the CT images were analyzed retrospectively. Results: Al the low dose MDCT image qualities of 22 cases (100%) meet the requirements of clinical diagnosis. Of the 22 preterm infants with BPD, ground-glass opacity lesions were found in 10 cases, and large sheet consolidation shadows with air bronchogram in 5 cases, the sac vesicular bright shadow in 5 cases, including diffuse pulmonary fibrosis in 3 cases. Conclusion: Low dose MDCT image quality can meet the requirements of clinical diagnosis the premature BPD, which has good clinical application value.