Objective Explore pediatric azithromycin treatment mycoplasma pneumonia role Methods Choose 78 cases of mycoplasma pneumonia patients with children, Random into 36 cases and erythromycin azithromycin group group 42 cases, Azithromycin and erythromycin were used to fight mycoplasma pneumoniae treatment. Result The average number of azithromycin fever 、Cough disappeared days、Chest radiograph shadow completely absorbed days (average cure days) Than erythromycin group reduced. The cure rate and the total effective rate was higher than erythromycin group. Adverse reaction rate for significantly less. Results Azithromycin treatment infantile pneumonia mycoplasma pneumonia better therapeutic erythromycin, Is worth further promotion and discussion.