Objective: To explore the smoking, drinking age correlation with primary liver cancer . Methods: 549 cases of primary liver cancer patients were systematicaly analyzed according to their smoking and drinking were divided into four groups, namely smoking and drinking group, the group of smokers without drinking , drinking and smoking group does neither smoking nor drinking group , respectively with a, B, C, D on behalf of the group, the average age of onset cases comparative analysis of the four groups of patients. Results: The mean age of onset for patients in group A (41.2 ± 8.4) years, the average age of onset group B patients was (47.6 ± 7.9) years, mean age of patients in group C was (48.3 ± 8.4) years old , D patients the average age was (57.4 ± 6.9) years of age , age of patients in group A was significantly lower than the other three groups , and there are differences (P <0.05), and D groups were more significant differences (P <0.01) , age of patients in group D at the latest . Conclusion: Drinking is a high risk factor in the pathogenesis of hepatocelular carcinoma dense , the incidence of primary liver cancer causes prolonged drinking of getting younger , the age of onset of smoking alone had no significant impact on primary liver cancer , but smoking and drinking At the same time the presence of the age of onset of primary liver cancer were significantly younger.