Objective To explore Neurotropin in treatment of lumbar disc caused by nerve root pain of curative effect. Methods Wil in February 2013 to February 2014 in our hospital diagnosis and treatment of 126 cases of lumbar disc as the main causes of sciatica patients were randomly divided into two groups: observation group 63 cases patients with Neurotropin treatment, 63 patients were treated dehydration treatment, to observe the curative effect of two groups. Result The two groups after treatment pain VAS scores as the change of time have significant difference, but the group of pain after treatment was observed obviously better than that of control group; 10 d after treatment the curative effect of observation group was obviously better than the control group. Conclusion Neurotropin in treatment of lumbar disc caused by nerve root pain clinical curative effect is distinct, And the security is good,it is worth wide application in the clinical practice.