Objective: To study the multi infarct dementia patient's clinical nursing methods and experience. Methods: from our hospital multi infarct dementia patients was performed on 37 cases study, carry out effective nursing intervention and psychological nursing for patients, health education as wel as the disease before and after nursing intervention, the patient's self-care ability and psychological depression compared. Results: after the treatment and nursing intervention of the activities of daily living and depression are better than before treatment, significant difference (P < 0.05), statisticaly significant. Conclusion: strengthening the basic nursing, life care and rehabilitation training can accelerate the recovery of patients with multi infarct dementia patients, improve patient outcomes.