尼莫地平治疗大面积脑梗死的临床疗效观察
The clinic control study of acute large-area cerebral infarction treated with nimodipine
王军 1李润辉 1赵丽宏1
作者信息
摘要
目的：观察急性大面积脑梗死早期应用尼莫地平静滴的临床疗效。方法选择急性发病的86例大面积脑梗死病人随机分成治疗组和对照组。治疗组予尼莫地平静滴，10毫克/日，连滴10天。对照组除不用尼莫地平外，其他治疗同治疗组。观察用药前、后两组NIHSS评分、Barthel指数和Rankin量表评分变化，比较两组疗效。结果治疗前两组NIHSS评分、Barthel指数和Rankin量表评分均无明显差异。治疗后治疗组NIHSS评分和Ranki评分均明显低于对照组，而Barthel指数均明显高于对照组，差异具有显著意义（P<0.01），结论早期静滴尼莫地平治疗急性大面积脑梗死疗效显著，副作用较小，安全性好。
Abstract
Objective To study the effect of early application of nimodipine injection on acute large-area cerebral infarction. Methods 86 patients diagnosed as large-area cerebral infarction were randomly divided into two groups(treatment group and control group). Nimodipine was given to the treatment group with 10mg each day for 10 days. The control group was given al treatment drug except nimodipine. The change of the NIHSS, Barthel Index (BI) and Rankin scales were adopted for statistical analysis to compare the differential effect between the two groups. Results NIHSS, BI and Ranki scales were comparable between two groups before treatment (P>0.05) . Compared with the control group, the Ranki scale of the treatment group was obviously decreased (P<0.01), while the NIHSS and BI scales were increased obviously after treated with nimodipine(P<0.01) . Conclusions Early use of nimodipine can lead to the improvement of neurological function in patients of acute large-area cerebral infarction securely and with few side effects.
关键词
大面积脑梗死/早期治疗/尼莫地平Key words
Acute large-area cerebral infarction/Early treatment/Nomodipine引用本文复制引用
出版年
2014
NETL
NSTL
万方数据