Objective To analyze the clinical features of liver disease in patients with hyperthyroidism. Methods for the diagnosis period March 2010 to February 2014 hospitalized patients with hyperthyroidism 190 cases, including 40 patients with hyperthyroidism, liver disease (study group), hyperthyroidism without liver damage 150 cases (control group). General comparison between the two groups, clinical manifestations, blood biochemistry. Hyperthyroidism, liver disease was the result of 21.1%, the older the higher incidence of hyperthyroidism, liver disease (P <0.05); hyperthyroidism, liver disease, 40 cases, only five cases (13%) of severe liver damage, and the remaining 35 cases (87%) were asymptomatic or mild hepatic dysfunction discomfort; research group ALT, AST, r-GGT, ALP, TT3, TT4 were higher (P <0.05), the difference between TSH between the study group and the control group was not statistical y significance (P> 0.05). Conclusion The patients with hyperthyroidism easily combined liver damage, liver damage symptoms or clinical manifestations of mild discomfort, mainly in the elderly and seriously il patients.