objective: to observe the iodine glycerin treatment of acute wisdom tooth pericoronitis of the clinical curative effect. Methods: choose 70 cases of patients with acute wisdom teeth pericoronitis, divided into two groups, the treatment group treated with topical flushing, blind bag placed iodine glycerin gelatin oil, cotton method; The control group with oral metronidazole tablets, observe its effect, the statistical analysis. Results: the treatment group compared with the control group was statistical y difference. Conclusion: iodine glycerin treatment of acute wisdom tooth pericoronitis curative effect is remarkable.