Relationship between fibrinogen, D- two dimer and vascular endothelial growth factor and diabetic retinopathy
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
目的：探讨分析血浆纤维蛋白原（FIB）、D-二聚体（D-D）和血清血管内皮生长因子（VEGF）与糖尿病视网膜病变（DR）的关系。方法行裂隙灯眼底检查和眼底荧光造影（F I A），将142例糖尿病分为糖尿病视网膜病变（D R）组74例，单纯糖尿病无视网膜病变（N D R）组68例，正常对照组62例。对上述三组人员血浆FIB、D-D和血清VEGF三项指标进行检测。结果142例糖尿病患者FIB、D-D、VEGF三项指标水平均高于正常对照组（均＜0.01）。DR组FIB、D-D、VEGF三项指标水平均高于无DR组（＜0.05），差异有统计学意义。结论 FIB、D-D、VEGF在糖尿病视网膜病变患者中明显增高，提示糖尿病视网膜病变组处于血液高凝状态和纤溶亢进，及血管内皮增生和通透性增加等病理变化，为糖尿病视网膜病变的预防、诊断和治疗提供参考依据。
Objective To investigate the analysis of plasma fibrinogen (FIB), two D- dimer (D-D) and serum vascular endothelial growth factor (VEGF) and diabetic retinopathy (DR) relationship. Method for slit lamp examination of fundus and fundus fluorescein angiography (FIA), 142 patients with diabetes were divided into diabetic retinopathy (DR) group of 74 cases, simple diabetic retinopathy (NDR) group of 68 cases, 62 cases of normal control group. Detection of three indexes of the three group FIB, plasma D-D and serum VEGF. Results in 142 cases of FIB, D-D, VEGF in patients with diabetes melitus and three indexes were higher than that of normal control group (< 0.01). In group DR, FIB, D-D, VEGF three indicators were higher than that of non DR group (P < 0.05), the difference was statisticaly significant. Conclusion FIB, D-D, VEGF were significantly increased in patients with diabetic retinopathy, suggesting that diabetic retinopathy group in high blood coagulation and fibrinolytic, and vascular proliferation and permeability of endothelial increased and pathological changes, to provide reference for the prevention, diagnosis and treatment of diabetic retinopathy.
fibrinogenD- two dimervascular endothelial growth factordiabetic retinopathy
NETL
NSTL
万方数据
