Uremic cutaneous pruritus in patients with chronic renal insufficiency is a common and unbearable symptoms of patients with maintenance hemodialysis incidence rate is as high as 60% - 90%. SAO is urticant symptom not only seriously affect the patient's sleep and work, and the symptom such as skin infections, skin damage and increased patients' risk of death. The author study of hemodialysis patients with skin itching reasons, and puts forward effective prevention and nursing, aims to provide evidences for clinical treatment and care.