血小板及纤维蛋白原水平对脑梗死患者阿司匹林抵抗的影响
The influence of the fibrinogen level and the amount of platelet to aspirin resistance in patients with cerebral infarction
张敏 1盛怀龙1
作者信息
- 1. 营口经济技术开发区中心医院神经内科 115007
- 折叠
摘要
目的：研究血浆中血小板及纤维蛋白原水平对脑梗死患者发生阿司匹林抵抗的影响。方法：100例均经头部C T或M R I证实为脑梗死的患者，服用阿司匹林100mg／d，疗程≥7天，用二磷酸腺苷和花生四烯酸作为诱导剂测定血小板聚集功能。根据血小板聚集试验结果将实验对象分为阿司匹林抵抗组（包括阿司匹林半抵抗组）、阿司匹林敏感组。结果：阿司匹林抵抗组血浆中血小板（P L T）及纤维蛋白原（F g）水平显著增高（P<0.01），结论：血浆血小板计数或纤维蛋白原水平增高患者更易发生阿司匹林抵抗。
Abstract
objective: To investigate the influence of the fibrinogen level and the amount of platelet to aspirin resistance in patients with cerebral infarction.Method: one-hundred patients with cerebral infarction which were determinded by CT or MRI taken aspirin 100 mg per day and no other antiplatelet agents at least 7 days. Diphosphate-induced platelet aggregation and arachidonic acid-induced platelet aggregation were analyzed. According to the platelet aggregation, the patients were divided into two groups: the aspirin resistance group(including the aspirin semi-resistrance)and the aspirin sensitivity group. Results: the fibrinogen level and the amount of platelet were significantly higher in aspirin resistance patients (P<0.01). Conclusions: Patients who have higher fibrinogen level or more amount of platelet easily generate aspirin resistance.
关键词
血小板/纤维蛋白原/脑梗死/阿司匹林抵抗Key words
platelet/fibrinogen/cerebral infarction/aspirin resistance引用本文复制引用
出版年
2014
NETL
NSTL
万方数据