首页|川崎病患儿血清胰岛素样生长因子1、胰岛素样生长因子结合蛋白3的变化研究

川崎病患儿血清胰岛素样生长因子1、胰岛素样生长因子结合蛋白3的变化研究

The study of the change in Kawasaki disease with children on insulin-like growth factor 1 and insulin-like growth factor binding Protein 3

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目的：探讨血清胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白3（IGFBP3）在川崎病病程及其治疗中的改变和临床意义。方法：川崎病组患儿分别于治疗前（病程第8天）、治疗后2、5天（病程第10、13天）采静脉血，其他感染性疾病组患儿于入院第1天及入院第5天采静脉血。以上标本均采用ELISA法进行IGF-1、IGFBP3测定。结果：（1）川崎病组治疗前（病程第8天）的IGF-1、IGFBP3血清水平较正常对照组升高（P<0.05），而与其他感染性疾病组（入院时）相比无显著性差异。（2）川崎病组治疗后2天（病程第10天），其血清IGF-1、IGFBP3水平与治疗前（病程第8天）相比明显升高，有显著性差异（P<0.05）。(3）川崎病组经治疗后5天（病程第13天），血清IGF-1、IGFBP3水平仍持续在高水平，与川崎病治疗后2天（病程第10天）相比无显著性差异，与正常对照组相比，差异有显著性（P<0.01），与其他感染性疾病组（入院后5天）相比明显升高（P<0．05）；其他感染性疾病组（入院时）与入院后5天血清IGF-1、IGFBP3水平相比无显著性差异（P>0.05）。(4）川崎病组分为发生CAL组和未发生CAL组，两组IGF-1、IGFBP3血清水平无显著性差异。（5）川崎病组中分典型KD和不完全KD两组，其治疗前后IGF-1、IGFBP3血清水平无显著性差异。结论：川崎病组患儿治疗后血清IGF-1、IGFBP3水平显著升高，可能与丙种球蛋白大剂量应用有关，其水平升高，可能减少了川崎病后期血管狭窄及血管瘤的形成，其作用机制有待进一步探讨。
Objective: To investigate the expression and clinical significance of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding Protein 3 (IGFBP3) in Kawasaki disease.Methods: The expression of IGF-1 and IGFBP3 in KD group serum blood, its course of the day 8、10、13 , were detected by means of ELISA. The serum levels of IGF-1 and IGFBP3with the infectious diseases group were detected by means of ELISA, in the hospital the first day and fifth day.Results: (1) The levels of serum IGF-1,IGFBP3 on the duration of 8 days in Kawasaki disease were higher than normal control group, compared with other infectious diseases group were not significant. (2)The duration of 10 days in Kawasaki disease , the serum IGF-1, IGFBP3 levels were significantly higher than the duration of 8 days .(P <0.05).(3)The duration of 13 days in Kawasaki disease , the serum IGF-1,IGFBP3 levels are stil continuing at high levels,compared with the duration of 10 days were not significant, compared with the normal control group , the difference was significant (P <0.01), compared with other infectious disease group (admission 5 days) was significantly higher compared (P <0.05). 1 days after admission with other infectious diseases group compared with 5 days after admission,the serum IGF-1,IGFBP3 levels showed no significant difference (P> 0.05).(4)Kawasaki disease patients were divided into two groups, with CAL group and without CAL group, two groups of IGF-1, IGFBP3 serum levels were not significantly different.(5) Typical Kawasaki disease group and atypical Kawasaki disease group, before and after treatment ,the IGF-1, IGFBP3 serum levels were not significantly different.Conclusion: After treatment with Kawasaki disease children ,the serum IGF-1, IGFBP3 levels were significantly increased, a large dose of gamma globulin related to its level rises possibly, it may reduce the Kawasaki disease and vascular stenosis late aneurysm formation, and its mechanism needs further study.

Kawasaki diseaseInsulin-like growth factor 1Insulin-like growth factor binding Protein 3

林莉、李雪梅、WANG Gui lan

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四川省自贡市第一人民医院儿科 643000

Department of Pediatrics,First People's Hospital of Zigong City, Sichuan Province, 643000

川崎病 胰岛素样生长因子1 胰岛素样生长因子结合蛋白3

2014

中外健康文摘
中国中医药报社

中外健康文摘

影响因子：0.016
ISSN：1672-5085
年,卷(期)：2014.(21)
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