Evaluation of hydrotalcite combined with omeprazole in treatment of gastric ulcer
0bjective To evaluate the clinical effect after the treatment of Hydrotalcite combined with omeprazole in the patients with active gastric ulcer.Methods One hundred twenty patients with active gastric ulcer and Helicobacter pylori(H.pylori)infection were randomized into the observation group(n=61)and control group(n=59).In the 1st week,control group received H.pylori eradication regimen, patients received omeprazole 20 mg /Amoxicilin 1000mg / Clarithromycin 500mg twice a day. In the 2nd to 6th week,the control group received omeprazole 20 mg 3 times a day . In the 7th to 8th week, the control group didn’t received drugs. On the basis of control group, the observation group received the Hydrotalcite Tablets(500mg, 3 times a day) for 8 weeks. Results After 1 days of treatment, upper abdominal pain remission rate in the observation group was was significantly better than the control group (P<0.05). After 8 weeks, there was no significant difference between the two groups on the ulcer healing rate evaluated by endoscopy(P>0.05). The recovery rate was significantly higher in the observation group(P<0.05). 1 years recurrence rate of the observation group was significantly lower than the control group(P<0.05). Conclusion In active gastric ulcer,the treatment of omeprazole combined WithHydrotalcite can better relieve the symptoms and improve the quality of ulcer and reduce the recurrence rate.
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