to analyze the psychological nursing inclinical treatment of psychosomatic disease. Methods: in our hospital from 2012 December -2013 year in Decemberduring the diagnosis and treatment of psychosomaticdiseases in 150 cases as the object of study, aretrospective analysis of clinical data of patients of the way,summarize the nursing countermeasures. Results: in thisgroup of patients with good clinical results obtained bypsychological nursing intervention of personalized, anxiety,and depression were significantly improved (P<0.05). Conclusion: psychological nursing intervention in patients with psychosomatic diseases personalized treatment process has a good clinical effect, can effectively aleviate the anxiety, depression, and help patients to establish theconfidence of treatment, worthy of promotion in clinical application.