观察α-硫辛酸联合依帕司他治疗2型糖尿病周围神经病变的临床疗效。方法选择2型糖尿病合并周围神经病变患者98例，均给予α-硫辛酸0.6 g 静滴每日1次，依帕司他50mg 口服，每日3次，连用3周。观察患者治疗前后神经系统症状及体征变化，并测定治疗前后患者四肢的神经传导速度、膝跟腱反射以及空腹血糖、血尿常规和肝肾功能等。结果α-硫辛酸联合依帕司他治疗后，患者神经系统症状及体征变化均明显好转，各神经传导速度与治疗前相比均有显著性差异(P<均0.05)。血糖、肝肾功能、血尿常规与治疗前比较无显著性差异(P 均>0.05)。结论α-硫辛酸联合依帕司他是治疗糖尿病周围神经病变安全、有效的药物。
Observation of the effect of α-Thioctic Acid combined with Epalrestat on diabetic perineuropathy
ObjectiveIt is to observe the clinical effect ofα- Thioctic Acid combined with Epalrestat on type 2 diabeticperineuropathy.Methods98 patients with type 2 diabetes complicating with melitus peripheral neuropathy were al givenα-Thioctic Acid 0.6 g once a day by intravenous drip and Epalrestat 50 mg three times a day by oral use. The treatment lastedfor 3 weeks. The changes of symptoms and signs of nerve system were observed before and after treatment, and nerve con-ductive velocity, knee jerk and achiles tendon reflex, fasting plasma glucose, blood and urine normal examination and liver-kidney function were detected too.ResultsAfter treatment withα-Thioctic Acid combined with Epalrestat, the changes ofsymptoms and signs of nerve system were obviously improved. There was a significant difference in nerve conductive velocitybefore and after treatment. Compared with those before treatment, blood sugar, liver-kidney function and blood urine normalexamination didn’t changes obviously after treatment (P>0.05).Conclusionα- Thioctic Acid and Epalrestat are safe andeffective drugs for treating for type 2 diabetic perineuropathy.
type 2 diabetesperipheral neuropathyα- Thioctic AcidEpalrestat
NETL
NSTL
万方数据
