探讨血清胱抑素 c 测定在慢性肾病早期诊断中的应用价值及干预措施。方法检测200例慢性肾病患者和50例健康体检者血清胱抑素 c、血肌酐（SCr）、尿素氮（BUN）水平，计算肾小球滤过率（eGFR）。结果3项观察指标均与血清胱抑素 c 相关，但血清胱抑素 c 与 eGFR 的相关程度最密切，在慢性肾病早期胱抑素 c 改变较其他指标更敏感。结论血清胱抑素 c 在慢性肾病各期均有较高的检出率，能敏感提示早期肾损害。
Objective To discuss the value and intervention mesures of using serum cystatin C in the early diagnosis of chronic kidney disease. Methods There were 200 cases of chronic kidney disease patients and 50 healthy subjects, accroding to serum cystatin C, serumcreatinine(Scr), blood urea nitrogen (BUN) levels, caculating glomerular filtration rate (eGFR). Results 3 observation indexes were relavent to serum cystatin C, but serum cystatin C closely related to eGFR , moreover in the early stage of chronic kidney disease cystatin C was more sensitive than other indicators. Conclusion Serum cystatin C is a sensitive mark of early renal damage, and in the chronic kidney disease the detection rate was high.
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