for newborns with acute respiratory failure (NRDS) of mechanical ventilation in the treatment of lung protective ventilation strategies in application effect is analyzed. Method: choose 74 cases of children with NRDS, randomly divided into two groups, control group 36 cases using the traditional ventilation method, observation group of 38 cases of lung protective ventilation strategy, compared two groups of blood gas analysis and complications. Results: observation group PaCO2 is significantly higher than the control group, the pH value was significantly lower than the control group, in hospital time was significantly shorter than control group; Observation group incidence of complications and mortality was significantly lower than the control group. Conclusion: mechanical ventilation in neonatal acute respiratory failure, lung protective ventilation strategy can make children reduce the incidence of ventilator associated lung injury, greatly shortened with the length of time, is worth promoting.