Objective Under the evaluation of percutaneous CT-guided needle lung biopsy histology joint cytology in the diagnostic value of pulmonary occupying lesions. Method 104 patients underwent pulmonary occupying lesions performed percutaneous CT-guided lung biopsy cytology simultaneously. Result 104 patients puncture success rate of 98.1%. Histologicaly accuracy of 89.4%, cytology accuracy of 85.6%, Both combined accuracy of 98.1% With the former two, respectively, the difference was statisticaly significant(P<0.05). Conclusion CT-guided percutaneous needle biopsy is a safe and High accuracy of diagnosis methods.