objective to explore the comfortable nursing and humanistic care in breast cancer postoperative intravenous transfusion nursing application. Methods select our hospital from January 2013 to March 2013 in our hospital and 46 cases of breast cancer patients in our hospital surgery, 46 patients were randomly divided into 23 cases of 23 cases of control group and experimental group, control group given routine postoperative intravenous transfusion nursing, the experimental group give comfortable nursing and humanistic care. To observe and contrast the two rent patients nursing before and after the change of quality of life. Results according to the Barthel index score, the postoperative self-care ability of daily life is better than the control group. Conclusion comfortable nursing and humanistic care in breast cancer postoperative intravenous transfusion nursing application effect is superior to conventional intravenous infusion nursing, postoperative suggested that clinical use.