To study the effect of severe craniocerebral trauma emergency nursing mode. Methods: 120 patients with severe craniocerebral injury were retrospectively analyzed, according to the sequence is divided into the observation group and the control group two groups, the routine nursing care as the control group, the observation group adopted one-stop emergency nursing mode, the effect of two groups were compared. Results: in the observation group was significantly better than the control group, by comparison with significant difference (P < 0.05).Conclusion: the implementation of one-stop emergency nursing mode can make the field first aid - transport, emergency room treatment, hospital treatment four key seamless connection, can significantly improve the success rate of severe craniocerebral trauma.