To explore the nursing experience of laparoscopic appendectomyoperation. Methods: 76 cases of patients were chosen in our hospital from appendixoperation were analyzed, and were randomly divided into control group andobservation group, the control group with routine nursing measures, to observe the implementation of the overal effective intervention group patients, compared two groups of patients with postoperative complications and patient satisfaction. Results: the implementation of the overal effective intervention group patients the incidence of postoperative complications was significantly lower than the control group, and the patients satisfaction was significantly better than the control group, by comparison with significant difference (P < 0.05). Conclusion: the laparoscopic appendectomy operation in patients with the implementation of holistic nursing intervention can significantly improve the clinical treatment effect, reduce the postoperative complications, and improve the satisfaction of patients.