objective to apply open renal partial resection with laparoscopic surgery two ways for the patients with renal disease to study the clinical effect of treatment. Methods in our fingers in 72 cases of patients with renal tumor diseases were randomly divided into control group and treatment group, an average of 36 cases in each group. Using conventional open renal resection treatment in patients with control group; Using laparoscopic surgery in the treatment group patients treatment. Results the treatment group effect in patients with renal tumor disease is better than the control group. Conclusion application of open renal partial resection with laparoscopic surgery two ways for the patients with renal disease treatment, clinical effect is very obvious.